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IUL Biotechnology Series, 6 |
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by Serge Moralev and Eugene Rozengart (Authors) |
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Edition: First |
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Book
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| Editorial Reviews |
| In review Book News, Inc.®, Portland, OR |
| Reviews |
| Dr. Leo Pezzementi, Birmingam-Southern College, Alabama |
| It has been more than thirty years since a book on cholinesterases of the ambitious scope and magnitude of Comparative Enzymology of Cholinesterases by S.N.Moralev and E.V.Rozengart has been available to Western readers. The previous book to which I refer, Biology of Cholinesterases by Ann Silver, was published in 1974 and synthesized much of the biological work in the field at that time. However, it was printed just before the discovery of the multiple molecular forms of cholinesterases and well ahead of the advent of cholinesterase molecular biology. Nevertheless, the book was a source of information, ideas, and inspiration for a generation of cholinesterase researchers. As a newcomer to the field at the time, who was interested in the structure, function, and evolution of cholinesterases, I found the comparative biological approach of Silver particularly valuable. It is well past time for a similarly comprehensive text summarizing the advancements in the research of cholinesterase over the past thirty years to be published. Moralev and Rozengart have responded to this need in a comprehensive book that reflects the changing times and the changing methodologies of cholinesterase research. The authors again take a comparative approach to cholinesterase research, but this time from a molecular/biochemical point of view rather than from a biological point of view. They synthesize a wide range of results from kinetics, pharmacology, and molecular biology, and apply these results to an investigation of the structure, function, and evolution of the cholinesterases in the vertebrates and the invertebrates. The authors consider the effect of substrate structure on substrate specificity and inhibition, and how these different inhibitors can be used alone and in conjunction with reversible and irreversible inhibitors to probe the various sub-sites of the active site of various cholinesterases. |
This
book fills the interdisciplinary gap between the integrated biology of
cholinesterase actions and their kinetic mechanisms. It covers structural and mechanistic
data on cholinesterase enzymes from a wide variety of living species
and their interactions with a diverse and original collection of
substrate and inhibitor compounds. The book
includes six chapters and appendices. The first part of the book (Chapters
1–4) deals with classical aspects of cholinesterase specificity in
substrate hydrolysis, inhibition by reversible inhibitors, and
progressive (“irreversible”) inhibition by organophosphorus compounds
and carbamates. The second part of the book (Chapters 5 and 6) deals
with the theoretical basis and the application of substrate–inhibitor
specificity for solving some practical problems: (a) calculation of
inhibitor selectivity toward different enzymes for identification of
reversible and irreversible inhibitors; and (b) the use of specificity
constants for molecular phylogenetic analysis of the active center of
cholinesterases and esterases. Comparison of computerized dendograms
with phylogenetic trees provides evolutionary and taxonomic information
that can lead to readjustments in the enzyme nomenclature.